Calculating federal payroll taxes is an important process for every business. It ensures that employees are paid the correct amount of money and allows businesses to remain compliant with federal regulations. To calculate payroll taxes, you need to first determine the total wages that were earned by the employee during the pay period. You then subtract any pretax deductions such as 401K or medical insurance premiums and use the result to calculate the applicable federal payroll taxes. This includes Social Security, Medicare and Federal Income Tax withholding. Once you’ve calculated each of these taxes individually, add them together to get the total federal payroll tax due. It’s essential to stay up-to-date on any changes in federal payroll regulations as they can affect your calculations.